bendamustine waldenstrom's macroglobulinemia

D'Acunto C, Purpura V, Scarpellini F, Liardo EV, Melandri D. JAAD Case Rep. 2020 Jul 22;6(10):981-983. doi: 10.1016/j.jdcr.2020.07.027. Adam J Olszewski, Steven P Treon, Jorge J. Castillo; Application and Outcomes of Bendamustine- or Bortezomib-Based Therapy for Waldenstrom's Macroglobulinemia.  |  Six rituximab-intolerant patients received bendamustine alone (n=4) or with ofatumumab (1000 mg I.V. Presented June 3, 2012. Tel - 212-372-7263, 2012 Copyright Knowledge is Power - All Rights Reserved, The National Cancer Institute is the leading authority on cancer and cancer treatment. Clin Lymphoma Myeloma. Conclusions: Although about half of older patients with WM/LPL in the US continue to be treated with rituximab alone, bendamustine and bortezomib have largely replaced classical cytotoxic agents for those who receive combination immunochemotherapy. Irene M. Ghobrial, Choice of Therapy for Patients With Waldenstrm Macroglobulinemia JCO January 20, 2013 vol. Cancer Treatment Today 228 Park Ave S #70464 Treon SP1, Hanzis C, Tripsas C, Ioakimidis L, Patterson CJ, Manning RJ, Sheehy P.Bendamustine therapy in patients with relapsed or refractory Waldenstrm’s macroglobulinemia.

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Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia. Treatment decisions may thus result from extrapolation of data on myeloma or other lymphomas. The proportion receiving bendamustine or bortezomib significantly increased between 2008 and 2014, displacing classical immunochemotherapy, but not rituximab monotherapy (Fig. Overall response rate was 83.3%, with 5 VGPR and 20 PR. 2017 May 23;8(21):35435-35444. doi: 10.18632/oncotarget.16130. Overall therapy was well tolerated. CHOP plus rituximab therapy in Waldenstrom's macroglobulinemia. Abstract 3. Clipboard, Search History, and several other advanced features are temporarily unavailable. Rummel MR, Niederle N, Maschmeyer G, et al: Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment in patients with indolent and mantle cell lymphomas: Updated results from the StiL NHL1 study. You can visit their site at. 2011 Feb;11(1):133-5. Gertz MA, Anagnostopoulos A, Anderson K, Branagan AR, Coleman M, Frankel SR, Giralt S, Levine T, Munshi N, Pestronk A, Rajkumar V, Treon SP. Treon: Pharmacyclics: Consultancy, Research Funding. 2018 Jan 1;10(1):e2018004. We evaluated patient characteristics associated with the use of classical immunochemotherapy, bendamustine, or bortezomib, in a multinomial logistic model, reporting relative risk ratio (RRR) with 95% confidence intervals (CI).

3 291-293. on either day 1 or 2) for 24 patients. on days 1, 2) and rituximab (375 mg/m2 I.V. The importance of the genomic landscape in Waldenström's Macroglobulinemia for targeted therapeutical interventions.

C). Fowler N, Kahl BS, Lee P, Matous JV, Cashen AF, Jacobs SA, Letzer J, Amin B, Williams ME, Smith S, Saleh A, Rosen P, Shi H, Parasuraman S, Cheson BD.

B). 31 no. Prolonged myelosuppression was more common in patients who received prior nucleoside analogues.He concluded that bendamustine is active and produces durable responses in previously treated WM, both as monotherapy and with CD20-directed monoclonal antibodies. In the multivariable model, patients treated with bortezomib were significantly more likely to be black than white (RRR, 7.49; 95%CI, 1.62-34.7; P=.010), more likely to be diagnosed as WM rather than LPL (RRR 2.38; 95%CI, 1.25-4.53; P=.008), and more likely to have chronic kidney disease (RRR, 3.18; 95%CI, 1.12-9.02; P=.029) or plasmapheresis before treatment (RRR, 2.99; 95%CI, 1.01-8.85; P=.048).

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